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Codeine is an opioid analgesic with very similar indications to All those of morphine, on the other hand, is a lot less strong in its ache alleviating Homes.cinacalcet decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Stops conversion of codeine to its Lively metabolite morphine.methylene blue and codein